Abstracts Accepted for Presentation:

Conference  Program

October 27, 2018

8:15 -8:45 Registrations

8:45-8:55 Kazuo Kojima, PhD, Dean, College of Life Sciences, Ritsumeikan University, Osaka, Japan. Welcoming Remark

8:55-9:20 Danik Martirosyan, PhD, President, Functional Food Center/Functional Food Institute, Dallas, TX, USA. Opening Remarks: FFC's Advancement of Functional Food Definition: Using this definition to evaluate scientific evidence

Session 1: Special Lectures

9:20-9:50 Yasuhito Shirai, PhD, Professor, Department of Applied Chemistry in Bioscience, Graduate School of Agricultural Science, Kobe
University, Kobe, Japan. Methylated epigallocatechin gallate (EGCg) as functional food for diabetic nephropathy

9:50-10:30 Hiroshi Maeda, PhD, Keynote Speaker, Nobel Prize Nominee for 2016, Professor Emeritus Kumamoto University (Med); Senior Invited Professor of Osaka University Medical School Director, and Director at BioDynamics Research Foundation, Kumamoto, Japan. Part 1: Cancer Problems, Free Radicals and Dietary Intervention; Part 2:Vigorous extracts of Meshimakobu mushroom (Phellinus linteus) and Kumaizasa bamboo (Sasa senanensis) leaf suppress cancer growth and carcinogenesis by oral administration 

10:30-10:45 Coffee Break

Session 2: Japanese Traditional Medicine (Kampo Medicine). Session Chair: Dr. Mikio Nishizawa

10:45-11:15 Mikio Nishizawa, MD, PhD, Professor, Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan. Anti-inflammatory effects of Japanese Kampo drugs and functional foods

11:15-11:45 Yukinobu Ikeya, PhD, Professor, Daiichi University of Pharmacy, Fukuoka, Japan.  Medicinal effects of food and crude drugs in relation to taste

11:45-12:15 Hojun Kim, PhD, OMD, Professor, Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, Goyang, Gyeonggi-do, Republic of Korea. Flos Lonicera combined with metformin ameliorates hepatosteatosis and glucose intolerance in association with gut microbiota modulation

12:15-13:15 Lunch

Session 3: Functional Food Ingredients: Sources and Potential Benefits in Public Health. Session Chairs: Dr. Hajime Fujii and Dr. Nashi Widodo

13:15-13:45 Almagul Kushugulova, MD, Head of Human Microbiome and Longevity Laboratory, National Laboratory Astana, Nazarbayev University, Astana, Republic of Kazakhstan. Saumal, mare's milk as a perspective functional food product

13:45-14:15 Hajime Fujii, PhD, President, Amino Up Chemical Co., Ltd., Sapporo, Hokkaido, Japan. Challenge empowering life with the power of nature

14:15-14:45 Nashi Widodo, PhD, Professor, Biology Department, Brawijaya University; Jl veteran, Malang, Indonesia. Introduction to Indonesia Traditional medicine of JAMU: from nature to the clinic

14:45-15:00 Coffee Break

Session 4: Traditional Medicines in China, Taiwan, South Korea, and Indonesia. Session Chairs: Dr. Mikio Nishizawa and Dr. Djati

15:00-15:30 I-Shu Lee,  Antrodia cinnamomea Association of Taiwan Treasure, Taipei city, Taiwan. Medicinal Mushroom Taiwanofungus camphoratus: A  potential cure for cancer

15:30-15:50 Shan Huang, MD, Director of VCC Preventive Medical Promotion Foundation, Director of the World Federation of Chinese Medicine societies, Diabetes Branch, Beijing, China. Integrated Medical Treatment of Psoriasis

15:50-16:20 Dinia Rizqi Dwijayanti and Mikio Nishizawa, MD, PhD, Professor, Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Japa n. The anti-inflammatory effects of Indonesian and Japanese bitter melon (Momordica charantia L.) extracts in interleukin-1β-treated hepatocytes

16:20-17:10 Poster Session (Session 5)

17:30-19:30 Evening Networking Reception: On the evening of October 27, 2018, we will be holding an enjoyable networking opportunity with us from 17:30-19:30 including live music. All attendees and speakers are welcome to come. This event will also be providing refreshments and appetizers, including beer, wine, champagne, Italian cheeses, salads, and more. Space is limited, and advance online registration is required. Please let us know if you are interested (ffc@functionalfoodcenter.com) 

October 28, 2018

Session 6: Traditional Medicines and Functional Foods: Session Chairs: Juliana Janet M. Puzon and Dr. Yosuke Hirayama

8:30-9:00 Juliana Janet M. Puzon, PhD, Institute of Biology, College of Science, University of the Philippines, Diliman, Quezon City, Philippines. Inflorescence, leaves and fruit peels of banana varieties as sources of bioactive secondary metabolites with antioxidant and antimicrobial activities

9:00-9:30 Ryou Sakamoto and Tominori Kimura, MD, PhD, Department of Pharmaceutical Sciences, College of Pharmacy, Ritsumeikan University, Kusatsu, Shiga, Japan.  Active Hexose Correlated Compound modulates the expression of endogenous EphA2 antisense RNA and suppresses the human breast carcinoma cell proliferation

9:30-9:50 Xiaoxiong Zeng, PhD, Professor, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China. Simulated digestion and in vitro fermentation by human gut microbiota of polysaccharides from the fruits of Lycium barbarum

9:50-10:20 Yosuke Hirayama, PhD, Amino Up Co., Ltd., Sapporo, Hokkaido, Japan. Effect of Welsh onion (Allium fistulosum L.) green leaf extract on immune response in healthy subjects: a randomized, double-blind, placebo-controlled study

10:20-10:30 Coffee Break

Session 7: Functional Foods and Bioactive Compound(s): Prevention and Management of Non-communicable Diseases. Session Chairs: Dr. Francesco Marotta and Dr. Kenji Sato

10:30-11:00 Shaoyu Wang, PhD, School of Community Health, Charles Sturt University, Orange, Australia.  What can yeast tell us about aging modulation by bioactive substances in functional food?

11:00-11:30 Francesco Marotta, MD, PhD, ReGenera R&D International for Aging Intervention, Milano, Italy. Mitochondrial and redox dysfunction in post-menopause as risk factor of neurodegenerative disease: testing the role of a validated Asian functional food.

11:30-12:00 Richi Nakatake, MD, PhD, Assistant Professor, Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan. Glutathione inhibits the expression of proinflammatory biomarker inducible nitric oxide synthase in hepatocytes

12:00-12:30 Kenji Sato, PhD, Professor, Graduate School of Agriculture, Faculty of Agriculture, Kyoto University, Kyoto, Japan. Presence of asparatic isopeptides in formulated liver protein hydrolysate-Structure and bioavaialbility

Lunch: 12:30-13:15

Session 8: Nutrition, Inflammation and Chronic Diseases . Session Chairs: Dr. Yoshinori Mine and Dr. Jun Nishihira

13:15-13:40 Jun Nishihira, PhD, Professor, Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu, Hokkaido, Japan . Epigallocatechin-rich green tea “Yabukita” increases serum adiponectin level: Investigation of its mechanism of action by exome analysis

13:40-14:00 Lujuan Xing, PhD Student, Department of Food Science, University of Guelph, Guelph, Ontario, Canada and Key Laboratory of Meat Processing and Quality Control, Nanjing Agricultural University, Nanjing, China. γ-glutamylvaline (EV) can prevent the low-grade chronic inflammation via the activation of CaSR pathway using a mouse 3T3-L1 cell model 

14:00-14:20 Shigeru Katayama, PhD, Faculty of Agriculture, Shinshu University, Nagano, Japan. Modulation of neuroprotective factors by bioactive food components and its mechanistic exploration 

14:20-14:45 Yoshinori Mine, PhD, Professor, Department of Food Science, University of Guelph, Ontario, Canada. Extracellular Calcium-Sensing Receptor (CaSR) as a new molecular target improving gastrointestinal chronic inflammation

14:45-14:55 Coffee Break 

Session 9: Current Research and Development of New Functional Food Products: Session Chairs: Dr. Mikio Nishizawa and Dr. Danik Martirosyan

14:55-15:25 Akira Uchiyama, PhD, Director of Wellness Research Laboratories, Research & Development Headquarters, Lion Corporation, Tokyo, Japan. Development of “Foods with function claims” in Japan: Effect of lactoferrin's visceral fat reduction and deep sleep increase of sake yeast

15:25-15:50 M. Sasmito Djati, PhD, Professor, Brawijaya University, East Java, Indonesia. Rempah-Rempah Indonesian traditional food flavor toward modern functional food and herbal medicine 

15:50-16:35 Poster Session: Session 10

16:35-16:40 Awards and Certificates

16:40-17:00 Conference Closing

Suggested Conference Sessions and Topics

Session 1: Functional Food Definition and the Status in Japan, USA, and other Countries

• The regulations, policy, and labeling of functional foods in Japan
• Weaknesses and strong points of FOSHU/Food for Special Health Usage
• What is the status of Functional Foods in the USA? Expert opinions from NIH, USDA, and FDA
• How the new definition of Functional Foods can help to improve the status of functional foods word wide

Special Session 2: Japanese traditional medicine (Kampo medicine)

• Kampo medicine: Differences between functional food, crude drugs, and low MW drugs
• Crude herbal drugs in Kampo medicine: How they can be used as functional foods
• Japanese traditional medicine (including Kampo medicine): How to assess its constituents
• Japanese traditional medicine: How to evaluate its activity on disease
• Pre-disease ('Mibyo' in Japanese): How to treat Mibyo with Kampo medicine consisting of functional foods

Special Session 3: Traditional medicines in China, Taiwan, South Korea, and Indonesia

• Chinese, Taiwanese, or Korean traditional medicines: Differences from Japanese traditional medicine
• Indonesian traditional medicine (Jamu): What is Jamu? Is Jamu crude herbal drugs or functional foods? Principles and Recipes of Jamu
• Pharmacological aspects of Jamu, such as anti-inflammatory, anti-diabetic, and anti-cancer effects

Special Session 4: Traditional medicines and functional foods

• How to find new functional foods using traditional medicine
• Food science: Qualification and quantification of beneficial components (e.g., HPLC and biological assays)
• Functional foods for animals, such as fish (as replacement for antibiotics)
• Development of functional foods on the market
• Food economics: food industries and functional foods on the market

Session 5: Functional Food Ingredients: Sources and Potential Benefits in Public Health

Session 6: Functional Foods for Chronic Diseases

6a: Nutrition, Functional, and Medical foods for Obesity

• Epidemiology of obesity
• The modern mechanisms of obesity; energy metabolism and obesity; neurobiological mechanisms of obesity; microbiological mechanisms of obesity; pathophysiologic mechanisms of obesity
• Biomarkers of obesity
• The effects of functional food and bioactive compounds on biomarkers of obesity
• Nutrition, Functional, and Medical foods for obesity

6b: Nutrition, Functional, and Medical foods for Diabetes

• Epidemiology of diabetes
• The modern mechanisms of diabetes
• Biomarkers of diabetes
• The effects of functional food and bioactive compounds on biomarkers of diabetes
• Nutrition, Functional, and Medical foods for diabetes

6c: Nutrition, Functional, and Medical foods for Neurological Diseases

• Epidemiology of mental and neurological diseases
• Mechanisms of neurological diseases
• Biomarkers of different mental and neurological diseases
• The effects of functional food and bioactive compounds on biomarkers of neurological diseases
• Functional foods for mental and neurological diseases
• Nutrition, Functional and Medical foods for neurological diseases

6d: Nutrition, Functional, and Medical foods for Cardiovascular Diseases (CVD)

• Epidemiology of CVD
• Biomarkers of different cardiovascular diseases
• The effects of functional food and bioactive compounds on biomarkers of cardiovascular diseases
• Nutrition, Functional, and Medical foods for CVD

6e: Nutrition, Functional, and Medical foods for Cancer

• Epidemiology of Cancer
• Biomarkers of different types of cancer
• The effects of functional food and bioactive compounds on biomarkers of different types of cancer
• Nutrition, Functional, and Medical Foods for the Cancer

Session 7: Functional Foods with Bioactive Compound(s): Prevention and Management of Non-communicable Diseases

• Functional foods and other non-communicable diseases
• Bioactive compounds and other non-communicable diseases
• The effects of medical food on biomarkers of non-communicable diseases

Session 8: Safety of the Bioactive Compounds and Functional Foods

• Food-Drug Interactions
• Safety of bioactive compounds at efficacious levels
• Safety of functional foods at efficacious levels
• Regulatory issues and health claims

Session 9: Biomarkers and Functional Food

• Biomarkers and functional foods
• Biomarkers available for assessing diet-related changes
• How can biomarkers improve functional food products development process?
• The importance of Monitoring Biomarkers in Functional food Science
• FDA’s Biomarker Qualification Program and creation of new functional foods

Special session 10: Bioavailability of bioactive compounds:

• Food structuring and bioaccessibility/ bioavailability
• Edible delivery systems for bioactive compounds
• Micro- and nano-encapsulation
• Impact of processing technologies/conditions on bioaccessibility/ bioavailability
• Underlying mechanisms of bioaccessibility/ bioavailability

Session 11: Current Research and Development of New Functional Food Products.

• Incentives for functional food research and development
• Consumer acceptance of functional food products
• Functional food composition and dietary intake databases
• Food vehicles for delivery bioactive compounds
• Research, development and marketing of new functional food products

Session 12: Nutritional Approach to Manage Chronic Allergies with Asian Traditional Medicine and Functional Foods

• Chronic allergies: What causes them and what are the symptoms?
• Asian Traditional Medicine in the management of food allergy
• Functional foods in the management of food allergy
• Dietary management of chronic food allergy in children
• The role of nutrition in the development and functioning of the immune system
• The role of prebiotics and probiotics in the prevention of chronic allergy

Welcome Letter

The Functional Food Center (FFC) is excited to announce the FFC’s 2018 International Conference titled “Encounters of Functional Foods and Asian Traditional Medicines.” This conference will be held on October 27 – 28, 2018 at Ritsumeikan University, Osaka-Ibaraki Campus in Osaka, Japan. We will be celebrating the 10th anniversary of the College of Life Sciences and the College of Pharmaceutical Sciences at Ritsumeikan University. The aim of this conference is to bring together leaders and experts in the field of functional foods to discuss and share ideas utilizing functional foods for medicine to combat various diseases.

The Functional Food Center currently defines “functional foods” as “natural or processed foods that contains known or unknown biologically-active compounds; which, in defined, effective non-toxic amounts, provide a clinically proven and documented health benefit for the prevention, management, or treatment of chronic disease.” Functional foods contain bioactive compounds to combat and treat nutrition-related diseases and can increase the physical and mental well-being of people. The idea of functional foods was first introduced in Japan in the early 1980s, and the functional food industry has since rapidly developed to become accepted throughout many countries around the world. Functional foods have become a very lucrative market in many Asian countries and have had a substantial growth in the past five years. There is typically less awareness of healthcare and healthcare facilities in Asia, which lead people to rely on functional foods as a source to prevent against diseases and illnesses. The use of medicinal herbs from foods has long been used in Asian culture for treating a vast variety of health ailments. Recent research on both functional foods and traditional Asian medicines have shown there to be many interlinking factors from both to be used to treat illnesses.

Dr. Mikio Nishizawa of the College of Biomedical Sciences at Ritsumeikan University will be co-chair of this conference. He began working at Ritsumeikan University in 2007 and has been studying about an antisense transcript-mediated mechanism to post-transcriptionally regulate the expression of the genes that are involved in inflammation, such as inducible nitric oxide synthase gene. Functional foods that affect the expression of these genes are other important targets of his research. Dr. Nishizawa was an outstanding lecturer in our previous 19th International Conference held in Kobe, Japan. We are excited to be working with Dr. Nishizawa again to make this conference a huge success.

Along with the other organizing committee members from universities throughout Japan and the FFC, Dr. Mikio Nishizawa proudly welcomes all to Ritsumeikan University and Osaka, Japan. We hope to bring together experts and those interested in the connection between Asian traditional medicines and functional foods to further discuss the progress in this field so far. We also hope to attract experts in the field of functional foods from around the world to present their findings on the use of functional foods to promote health and prevent disease. Osaka has much to offer with its rich culture and blend of modern architecture and nightlife. The 16th-century shogunate Osaka Castle is one of the major historical landmarks to visit, and the unique varieties of street foods are not to be missed. We look forward to welcoming you our conference at Ritsumeikan University and enjoy the robust culture of Osaka, Japan.

We would like to invite anyone interested in speaking or organizing special sessions for the conference. Organizers will be responsible for creating a special sessions and finding speakers who would like to speak in their session. Speakers and organizers will need to provide a short bio (with image) and biosketch. Again, we are very excited to present to you the 2018 International Conference by the FFC held at Ritsumeikan University, Osaka-Ibaraki Campus in Osaka, Japan: “Functional Foods and Asian Traditional Medicines,” and appreciate your efforts to make this conference a success.

Venue and Accommodation

Ritsumeikan University Osaka Ibaraki Campus

Ritsumeikan University Osaka Ibaraki Campus Map: http://en.ritsumei.ac.jp/file.jsp?id=246777&f=.pdf

Description of Osaka Ibaraki (http://en.ritsumei.ac.jp/lifecareer/about/)

Ibaraki city is located between Kyoto and Osaka, Japan’s third-largest city. While having many ancient tombs including the Oda Chausuyama-kofun Burial Mound (Mausoleum of Emperor Keitai), the city is well supplied with commercial districts, supermarkets and large shopping centers near the stations and across the city. The northern part of Ibaraki city is filled with scenic nature including the Oinosaka mountain range and Tanba Plateau. Ritsumeikan University Osaka Ibaraki Campus is built in an urban area situated in the southern half of the city. There are also many parks and areas of greenery within the city, one of which being the remarkable Expo ’70 Commemorative Park.

The history of Ritsumeikan dates back to 1869 when Prince Kinmochi Saionji, an eminent international statesman of modern Japan, founded "Ritsumeikan" as a private academy on the site of the Kyoto Imperial Palace. In 1900, Kojuro Nakagawa, former secretary of Prince Saionji, established Kyoto Hosei School, an evening law school that was open to working people. This school formally adopted the name Ritsumeikan in 1913 and was finally given the status of a university in 1922. 

Today, Ritsumeikan University offers a wide range of courses in advanced studies at its Kinugasa Campus in Kyoto, Biwako-Kusatsu Campus (BKC) in Shiga and Osaka Ibaraki Campus (OIC) in Osaka. The year 2000 marked the 130th anniversary of the founding of the Ritsumeikan private school and the 100th year of the establishment of Ritsumeikan University.

Osaka Ibaraki

Ibaraki city is located between Kyoto and Osaka, Japan’s third-largest city. While having many ancient tombs including the Oda Chausuyama-kofun Burial Mound (Mausoleum of Emperor Keitai), the city is well supplied with commercial districts, supermarkets and large shopping centers near the stations and across the city. The northern part of Ibaraki city is filled with scenic nature including the Oinosaka mountain range and Tanba Plateau.

Accommodations: Recommended Hotels

1. Hotel name: Hotel Crest Ibaraki Address: Matsugamotocho 1-8, Ibaraki, Osaka 567-0033, Japan TEL: +81-72-620-2020 FAX +81-72-624-9112 Website: http://www.hotel-crest.co.jp/crest_ibaraki/

2. Hotel name: Hotel Crest Dio Ibaraki Address: Ekimae 1-3-2, Ibaraki, Osaka 567-0888, Japan TEL: +81-72-620-1010 FAX +81-72-622-4666 Website: http://www.hotel-crest.co.jp/crest_dio/index.html

Closest station:

Located just outside JR Ibaraki Station, Hotel Crest Ibaraki offers convenient access to Osaka, Kyoto and Kobe. Great for both business and leisure travelers with easy access from Kansai Airport, this 165-room hotel features a relaxing large public bath featuring an outdoor bath, as well as meeting rooms and a restaurant offering breakfast service. Rooms feature a modern decor and come equipped with a TV, refrigerator, as well as several other convenient amenities. LAN and WiFi service available as well.

One min walk from JR Ibaraki station ( Ibaraki station is 10 min by train from Shin-Osaka station ) / 70 min by Express Limousine Bus from Kansai International Airport / 30 min by Osaka Monorail from Osaka International Airport ( also known as Itami Airport )

2. Hotel name: Hotel Crest Dio Ibaraki

Address: Ekimae 1-3-2, Ibaraki, Osaka 567-0888, Japan

TEL: +81-72-620-1010
FAX +81-72-622-4666

Website: http://www.hotel-crest.co.jp/crest_ibaraki/

Tourism:

Universal Studios Japan: Theme Park; Universal Studios Japan, located in Osaka, is one of four Universal Studios theme parks, owned and operated by USJ Co., Ltd., which is wholly owned by NBCUniversal.   http://www.usj.co.jp

Osaka Castle: Osaka Castle is a Japanese castle in Ch??-ku, Osaka, Japan. The castle is one of Japan's most famous landmarks and it played a major role in the unification of Japan during the sixteenth century of the Azuchi-Momoyama period  https://www.osakacastle.net

Dotonbori: The name “Dotonbori” generally refers both to the Dotonbori Canal and to Dotonbori Street which runs parallel to the canal’s southern bank. It is one of the most colorful areas in Osaka and an absolute must-visit location when traveling through Kansai region. The lively entertainment area of Dotonbori is Osaka’s most famous tourist destination and renowned for its gaudy neon lights, extravagant signage, and the enormous variety of restaurants and bars. https://www.osakastation.com/dotonbori-area-the-bright-heart-of-osaka/

Osaka Aquarium Kaiyukan: The Osaka Aquarium Kaiyukan is an aquarium located in the ward of Minato in Osaka, Japan, near Osaka Bay. It is one of the largest public aquariums in the world, and is a member of the Japanese Association of Zoos and Aquariums.  http://www.kaiyukan.com

Shitenno-ji: Shitenno-ji is a Buddhist temple in ?saka, Japan. It is sometimes regarded as the first Buddhist and oldest officially administered temple in Japan, although the temple buildings have been rebuilt over the centuries.  http://www.shitennoji.or.jp

Nishinomaru Garden: Picturesque city park known for its manicured lawns, sculpted topiary & cherry blossoms.  https://osakacastlepark.jp

Umeda Sky Building, Kuchu Teien Observatory: The observation platform of this observatory is a bridge connecting the two towers of the Umeda Sky Building, whose roof features a doughnut shape that provides an unobstructed 360-degree view. While enjoying the breathtaking sights you can also directly feel the wind?which at 170 meters off the ground can get quite strong. From this observatory you can not only see all of Osaka but as far away as Awaji Island. The basement of the building houses the Takimi-Koji gourmet street with old fashioned images of Osaka from the 1920s.  https://osaka-info.jp/en/page/umeda-sky-building

Tempozan Ferris Wheel: Tempozan Ferris Wheel is located in Osaka, Japan, at Tempozan Harbor Village, next to Osaka Aquarium Kaiyukan, one of the largest aquariums in the world. The wheel has a height of 112.5 metres and diameter of 100 metres.  http://www.senyo.co.jp/tempozan/

Tennoji Zoo: The zoo's approximately 11 hectares house 1,000 animals of 200 different types, including everything from lions, and chimpanzees, to the always-popular koalas, New Zealand kiwis (which can only be viewed at the Tennoji zoo), and distinctive, black-headed drills. In addition to attempting to reproduce the animals' natural habitats as closely as possible, the Tennoji Zoo also serves as a kind of ecological exhibition, introducing the public to the way these animals live. 

http://www.city.osaka.lg.jp/contents/wdu170/tennojizoo/

https://osaka-info.jp/en/page/osaka-tennoji-zoo